Father Mesure was ordained as a priest in 1984. His previous parish assignments include Parochial Vicar, Saint Dorothy Parish, Drexel Hill; Parochial Vicar and later Pastor, Saint Charles Borromeo Parish, Bensalem; Pastor, Good Shepherd Parish, Philadelphia; Pastor, St. Gertrude Parish, West Conshohocken; and Pastor, Saint Mary Parish, Conshohocken. Father Mesure studied canon law at The Catholic University of America (J.C.D.) and American law at Villanova Law School (J.D.). He has also had various assignments with the Archdiocese, including the Clergy Office, Tribunal, Office for Child and Youth Protection, and currently as the Coordinator for Archdiocesan Pastoral Planning Initiatives and as the Chancellor of the Archdiocese.